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Food plan Excessive in n-3-PUFAs Linked to Decrease Breast Most cancers Threat

TUESDAY, Aug. 16, 2022 — A eating regimen excessive in n-3 polyunsaturated fatty acids (PUFAs) is related to a lowered threat for breast most cancers amongst ladies in China, based on a examine printed on-line July 26 in Menopause.

Zhuo-Lin Zhang, M.D., from Solar Yat-sen College in Guangzhou, China, and colleagues examined the associations between breast most cancers threat and consumption of n-3 PUFAs in Chinese language ladies in a case-control examine, together with 1,589 instances and 1,621 age-frequency-matched controls. A validated meals frequency questionnaire was used to evaluate dietary knowledge.

The researchers noticed an affiliation for greater consumption of marine n-3 PUFAs and complete n-3 PUFAs with a decrease threat for breast most cancers, with adjusted odds ratios of 0.68 and 0.56 for quartile 4 versus 1, respectively. Inverse associations had been additionally seen for dietary alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid with breast most cancers threat, with adjusted odds ratios of 0.51, 0.68, 0.68, and 0.76, respectively. These inverse associations had been stronger for premenopausal ladies and ladies with estrogen receptor (ER)-positive, progesterone receptor (PR)-positive, and ER-positive PR-positive tumors. In overweight/chubby ladies, however not in ladies of regular weight, a lowered threat for breast most cancers was considerably related to rising n-3 PUFA consumption. A major interplay was seen for linoleic acid and marine n-3 PUFAs.

“This examine highlights the impact of way of life habits and, particularly, dietary consumption of polyunsaturated fatty acids on breast most cancers threat,” Chrisandra Shufelt, M.D., president of the The North American Menopause Society, stated in a press release.

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